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Opioids were designed to reach receptors in the brain, causing pain reduction and feelings of euphoria

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This augments mitochondrial membrane potential, which decreases the rate of electron transfer through the ETC leading to electron leak and exacerbated ROS generation

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It was hypothesized during this investigation that these components might be "somatomedins," leading to the designation of these compounds as "insulin-like growth factors." (1) Further explorations into the insulin-like growth factors involved gene-targeting approaches to potentially enhance their bioavailability and potency