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Epilepsia Open 4:563571

discovered that metformin inhibits the mitochondrial respiratory chain complex to prevent the electron transport from NADH to coenzyme Q, which somewhat lowers mitochondrial basal and maximal respiration and mildly limits ATP synthesis

Accessed 24 Mar 2023

First, the TCA enzyme mitochondrial aconitase (ACO2), which catalyzes the reversible isomerization of citrate to isocitrate 56 , has a [4Fe-4S] cluster at its substrate-binding site