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The functioning of the pituitary gland and the hormones it secretes decreases with aging, however, IGF-1 is capable of bypassing the pituitary gland and is able to elicit the same response as GH does

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J Pharm Sci 86(3):378383 Sugibayashi K, Hayashi T, Morimoto Y (1999) Simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin after its topical application: the effect of enzyme distribution in skin

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