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Similarly, Lactobacillus rhamnosus Probio-M9 enhances anti-PD-1 efficacy in preclinical models by expanding commensal populations that produce immunomodulatory metabolites (butyrate, -ketoglutarate), which suppress Treg differentiation while activating CTLs (254)

Prins ML, Matsumoto JH

Moreover, FMT studies validated that the microbiota-modulating properties of AMP1-1 significantly alleviated weightlessness-induced bone loss

Universidade Federal de Viosa, Viosa, Minas Gerais State, Brazil Ricaboni D, Mailhe M, Benezech A, Cadoret F, Fournier PE, Raoult D (2017) Acidaminococcus timonensis sp

Leucine-mediated mTORC1 signaling thus integrates nutrient availability with immune activation, highlighting its role in balancing inflammatory and regulatory responses