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In vitro studies revealed that HOCl modifies and inactivates 1 -antiproteinase and 2 -macroglobulin, both of which are known to inhibit several proteolytic enzymes released from microbes and neutrophil granules in extracellular fluids [153, 319, 320]

Schnider, C

Anal Chim Acta 247:125132 Kzlta H, Bingol Z, Goren AC, Pnar SM, Alwasel SH, Glin (2021a) LC-HRMS profiling of phytochemicals, antidiabetic, anticholinergic and antioxidant activities of evaporated ethanol extract of Astragalus brachycalyx FISCHER

Of note, NO avidly binds iron and is known to attack the active sites of a multitude of proteins, including heme and iron-sulfur clusters ([Fe-S]) [1]

thetaiotaomicron and Clostridium clusters IV and IXa following the fermentation of dietary fibre (Roediger 1980