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However, these approaches are often limited by issues such as drug resistance, rapid metabolism, and significant side effects [9, 10]

Despite RIC is classified as an autosomal recessive disorder, five of the seven Japanese patients with RIC in a retrospective study were compound heterozygous, and two were simple heterozygous with a single variant of the ATP8B1 or ABCB11 genes

In addition, the discovery of the first specific LDHB inhibitor was recently reported 61

The cost of that breadth is that it leans on mechanism and individual trials rather than a single combination headline

DL-Threo- -benzyloxyaspartate (TBOA) is a glutamate uptake blocker frequently used to induce excitotoxicity