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46 Effective covalent library design merges classical FBDD parameters 47 (rule of three) with warhead characteristics like reactivity, stability, and reaction geometry

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Closing Perspective on 5Amino1MQ 5-Amino-1MQ represents a shift in metabolic research from hormonal manipulation to cellular optimization. By targeting the NNMT enzyme, it addresses a fundamental inefficiency in the metabolism of obese and aged cells