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Right panel : High-dose IV ACh causes more profound systemic vasodilation and additionally exerts direct effects on cardiac M2 receptors in the sinoatrial (SA) node, suppressing pacemaker activity

Valdivia A et al

Medications: Some medications, such as hormone replacement therapy, chemotherapy and certain antibiotics, can increase sensitivity to sunlight and cause pigmentation as a side effect

100,120,121,122 An N-terminal intrinsically disordered peptide sequence has been shown to bind another haem moiety, although its function remains to be determined