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The finding that 5 of 11 vitamin B 12 deficiency patients without a history of gastrectomy complained of tongue pain in the absence of any significant pathologic oral signs suggests that blood examinations, including vitamin B 12 measurements, are mandatory for patients with glossodynia

More importantly, ROS appears to involve in the Fe 2 O 3 NP-induced macrophage activation through several signal pathways, consequently regulating the innate immune response (Mulens-Arias et al., 2021)

So far, no Tolerable Upper Intake Level (UL) has been established for B12

For matching the background characteristics of the two groups, measures such as propensity score matching, could be considered

SPANISH VEGETARIAN POPULATION: B12 AND METHYLMALONIC ACID 4.2 "OFFICIAL" RECOMMENDED DAILY AMOUNTS AND SUPPLEMENTATION 4.3 VITAMIN B12 IN OVO-LACTOVEGETARIANS 5