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Inflammatory conditions in the ankle joints markedly decreased in the groups of PDA, PDA@Pt, and PDA@Pt + Laser as assessed by Hematoxylin and Eosin (H&E) staining (Fig

This reduces oxidative stress and keeps cells from getting damaged

To that end, an E3 ligase activity-deficient mutant of UBR5 was generated by mutating the critical residue cysteine 2768 to alanine (UBR5C2768A, Mut-UBR5), as previously reported 39