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The results showed a significant negative relationship between UA levels and the progression rate of ALS [130]

4.9 Ferroptosis in Huntingtons disease HD is an autosomal dominant neurodegenerative disorder caused by CAG repeat expansions in the HTT gene, which encodes mutant huntingtin (mHTT) proteins containing elongated polyglutamine (polyQ) tracts

Choline is also a major source for methyl groups via its metabolite, betaine, which participates in S-adenosylmethionine synthesis pathways [4]

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2012 Aug;56(2):727-34