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In which, MMDX is nuclear-targeted analogue activated by the liver enzyme cytochrome P450 3A and metabolize into a cytotoxic metabolite and degrades slowly [103]

At 428.101(a), we proposed to identify a Part D rebatable drug [683] for each applicable period by determining which covered Part D drugs, as defined in section 1860D-2(e) of the Act, meet the requirements in section 1860D-14B(g)(1)(C) of the Act (that is, are brand name drugs approved under an NDA, biologicals licensed under a biologics license application (BLA), or generic drugs approved under an ANDA)

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Flavonoids may have an additive effect to the endogenous scavenging compounds

Furthermore, -KG, which is produced from pyruvate in the TCA cycle, is known for its ability to bind to and remove ROS, a contributor to oxidative stress 24