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To address these limitations, antibody-drug conjugates (ADCs) have emerged as a promising class of therapeutics, combining the target specificity of mAbs with the high cytotoxic potency of chemotherapeutic agents

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In our study using INS-1 cells, we demonstrated that ceramide induces -cell apoptosis by promoting mitochondrial dysfunction, activating NF-B, and upregulating TXNIP, an endogenous inhibitor of thioredoxin, which disrupts redox balance and reduces insulin gene expression

euvesicatoria (Nol et al., 2002

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