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This paper provides evidence that IL-6 trans -signalling via sIL-6R is responsible for high-fat diet-induced recruitment of macrophages into adipose tissue

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188 Coincidentally, tumor-produced lactate induces H3K18la in macrophages, thereby activating transcription and enhancing pro-tumor macrophage activity

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Some biological activity remains, but titrating dose upward to compensate introduces cost and potential side effects without addressing the root problem

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