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doi: 10.1038/s41396-019-0364-5 94 AcharyaCBetrapallyNSGillevetPMSterlingRKAkbaraliHWhiteMBet al

10.1002/ptr.8169 16 BhandariR.KuhadA

Endocrine Oncology Warning: Thyroid C-Cell Tumor Risk Animal studies showed thyroid C-Cell tumors, and labeling carries a boxed warning based on those findings

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In phi and tau GST enzymes, the active site, characterized by the presence of a conserved serine residue, activates the sulfur atom in the cysteine residue in GSH (i.e., lowers its pKa), forming reactive thiolate species (Cummins et al