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Studies measuring the acetoacetate/beta-hydroxybutyrate in different brain regions with aging and DR are needed to determine the extent to which DR leads to a reduction of the brain mitochondrial [NAD + ]/[NADH], possibly driving neuroprotection and slowing the rate of brain aging

Although neurodegeneration is tightly bound with the concept of protein aggregation, it is not the sole contributor

Majewski M, Lis B, Jukiewicz J, Ognik K, Jedrejek D, Stochmal A, Olas B

The presence of TM in the shiro was verified using TM-specific primers (DTmF, DTmR) under the conditions described in a previous study [46]

Mitochondrial DNA (mtDNA) copy number was not significantly altered in either of the conditions (Fig