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Dass et al., 2003

Until now, regulatory uncertainty has made consistent access and prescribing workflows more complicated

Surprisingly, MdfA also confers resistance to therapeutically significant antibiotics with unrelated chemical structures, including erythromycin, chloramphenicol, certain aminoglycosides, and fluoroquinolones ( When mdfA and acrAB are overexpressed together, quinolone resistance increases synergistically

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(1) Systemic entry and uptake: Tyramine escapes normal intestinal and hepatic metabolism, enters the circulation, and is transported into sympathetic nerve terminals via the norepinephrine transporter (NET)