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Pellets were resuspended in DMEM/F-12 medium (Life Technologies, Carlsbad, CA, USA) supplemented with 20% foetal bovine serum (FBS, Pan Biotech, Aidenbach, Germany) and penicillin/streptomycin (Life Technologies) and plated on 10 cm cell-culture dishes

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Insist on detailed Certificates of Analysis (CoAs) for specific batches, which should verify purity (e.g., via HPLC), heavy metal limits (Pb, As, Cd, Hg), and microbial contamination against Japanese Pharmacopeia (JP) or other international standards (USP, EP)

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Moreover, the regulation of CSC fate has been associated with FOXOs [264]

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