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lipid lowering agents e.g., HMG-CoA reductase inhibitors such as simvastatin and lovastatin which are marketed as ZOCOR and MEVACOR in lactone pro-drug form and function as inhibitors after administration, and pharmaceutically acceptable salts of dihydroxy open ring acid HMG-CoA reductase inhibitors such as atorvastatin (particularly the calcium salt sold in LIPITOR@), rosuvastatin (particularly the calcium salt sold in CRESTOR), pravastatin (particularly the sodium salt sold in PRAVACHOL), fluvastatin (particularly the sodium salt sold in LESCOL), cerivastatin, and pitavastatin

Second, the gut microbiota-ferroptosis axis in humans remains poorly defined

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Species can also differ between individuals due to differences in enterotype, body mass index, exercise frequency, lifestyle, and cultural and dietary habits [51]

Orally administered drugs are often absorbed in the gastrointestinal (GI) tract and transported directly to the liver via the portal circulation (Fig