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To investigate mechanisms underlying FTLD-GRN, single-cell transcriptomics in the thalamus and frontal cortex of Grn / mice and FTLD-GRN patients identified a conserved astrocytic pathology marked by upregulation of GJA1, AQP4 , and Apoe , and downregulation of the glutamate transporter SLC1A2

Modulation of the receptor functions by thiol-modulating agents

doi: 10.1016/j.celrep.2021.109989 126 SpoonerR.YilmazO

There are over 50 elements classified as heavy metals, with 17 considered particularly toxic

S-adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1