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Although mitigation measures were implemented, this resulted in fewer participants than planned enrolled into the severe renal impairment group

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These findings suggest that water deprivation exacerbates renal medullary damage in DM mice, impairing urine concentration and leading to polyuria, while renal fibrosis likely contributes to reduced filtration function, as evidenced by elevated serum creatinine levels

Measured GFR as a confirmatory test for estimated GFR

HEK 293 cells were treated with HGF +/- Dihexa and analyzed for phosphorylated (activated) c-Met by by immunoblotting