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Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism

Interestingly, improved supply of GSH precursors from astrocytes to neurons and a thereby better resistance of neurons has been reported after adrenergic stimulation (Yoshioka et al

In addition, the NLRP3 inflammasome activation triggered by ROS was also reported in the ARHL and NIHL

Furthermore, as adipose tissue constitutes a vital source for stored energy and acts as an important endocrine organ, understanding the etiology of its wasting is critical to developing a treatment for cachexia