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K-means clustering of amplicon sequence variant data confirmed that 5-Amino-1MQ treatment generated a distinct cecal microbiome profile from all other treatment groups including diet-switched vehicle controls indicating that NNMT inhibition produces microbiome changes that are separable from those produced by dietary composition alone

Dutasteride is stronger but has a different safety profile and is often used off-label

Specific objectives Primary objectives Measure whether daily maternal administration of 50 g vitamin B 12 from early pregnancy until 6 months postpartum improves cognitive, language and motor scores of the Bayley-III measured at 6 and 12 months of age

In diet-induced obese (DIO) mouse models, NNMT inhibition led to approximately 35% reduction in white adipose tissue mass compared to controls

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