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doi: 10.1016/j.jtho.2019.10.004 71 KojimaTShahMAMuroKFrancoisEAdenisAHsuCHet al

The identified and quantified peptides were as follows: for PrpC, GLAGVVVDTTAISK, GELPTDAELALFSQR and VVPQTNSLTYR

Funnel plots with symmetrical scatter and the p-value more than 0.05 of Beggs test were regarded as having a low risk of publication bias

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16.2 10 6 cm/s and 13.2 10 6 cm/s when tested at 10 M respectively ( P app of 31.8 10 6 cm/s, while 7-hydroxymitragynine P app was 15.3 10 6 cm/s ( P app of 3.3 10 6 cm/s when tested at 5 M, and 3.4 10 6 cm/s when tested at 10 M ( 4.2 Interactions With Membrane Transporters Physiological barriers not only act as a physical barrier which is contributed by the restrictive tight junctions, but also as metabolic and transport barriers to permeation of molecules ( Evidence on mitragynine and 7-hydroxymitragynine P-gp-mediated efflux are conflicting (Table 4)