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In December 2016, as part of the Water Infrastructure Improvements for the Nation Act (WIIN Act) that included support for Flints pipe replacement work, Congress funded a four-year grant (2017-2021) to Centers for Disease Control and Prevention (CDC) for the creation of a Flint Lead Exposure Registry

The therapeutic potential of NIK has been demonstrated by the finding that a small-molecule inhibitor of NIK, SMI1, alleviates disease severity in mouse models of SLE, characterized by decreased B cell numbers and autoantibody production, improved kidney function and reduced kidney inflammation [113]