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These results emphasize the role of oxidative stress in cisplatin-induced hepatotoxicity and highlight the hepatoprotective capacity of antioxidant agents

Lidan Zhao, [email protected] These authors have contributed equally to this work This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Cu + can also bind to transcription factors in the cell nucleus, thereby affecting gene expression and subsequent protein synthesis (21)