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These conditions may be linked to mitochondrial gene mutations, such as those in the Parkin, PINK1, and DJ-1 genes, which are associated with the development of PD, as well as exposure to toxic substances that can damage mitochondria, including heavy metals and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) (Hao et al., 2010

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