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Cytometry 17(1):84-93, 1994

A significant limitation of permeation enhancers is the potential for local mucosal irritation, impaired ciliary function, and epithelial disruption, particularly when surfactant-type enhancers are utilised at elevated concentrations or with prolonged exposure (Maher et al., 2019

However, the researchers observed systemic effects from oral Livagen, suggesting either that sufficient amounts survived to reach target tissues or that local effects in the gastrointestinal tract produced systemic benefits

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