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36 , e0000823 (2023 Antimicrobial Resistance Collaborators Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

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FIGURE 6 3 Intestinal Flora Mediated Metabolic Activation of Natural Products Leading to Toxicity Gut flora extensively implicates in the metabolism of multiple medicinal drugs, consequences for interpersonal variation in drug or xenobiotics toxicity (Zimmermann et al., 2019

In addition, increasing neutrophils may contribute to the progression of AS through phagocytosis, ROS production damaging tissue and impairing endothelial function, repairing damaged tissues, restricting NET production, or directly releasing NET to counter inflammation, which may be beneficial for the progression of AS (203)

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