Equine Vet J Suppl
However, the most common presentation of CP-induced nephrotoxicity is acute kidney injury (AKI) (Miller et al., 2010), which is characterized by the rapid decline of renal excretory function leading to the accumulation of nitrogenous waste products, water, and electrolytes (Ostermann and Joannidis, 2016
Aside from protecting cells from damage due to excessive oxygen or nitrogen radicals, glutathione plays a number of other key roles, including (1) : Detoxification of toxic compounds Facilitating plasma membrane transport of toxic substances for elimination Scavenging oxygen and nitrogen oxidants Recycling and regenerating other antioxidants (vitamins C and E) Removing heavy metals Regulating cell proliferation and apoptosis Supporting mitochondrial function and maintaining the health of mitochondrial DNA Without sufficient glutathione production or intake, low glutathione status can contribute to the development or worsening of various disease states, some of which include (2, 3) : Premature aging Neurodegenerative disorders (Alzheimers, Parkinsons) Cancer Diabetes HIV/AIDS Autoimmunity Infertility Mental health disorders Its a little nutrient that plays a big role, so supporting it in any way you can is critical to maintaining health and preventing chronic disease development
PhoA accumulation was analyzed by SDS-PAGE (NuPAGE 4 bis 12 %, Bis-Tris, Invitrogen, Waltham, MA, USA) and Western blot analyses were carried out using nitrocellulose membranes in the iBLOT2 system (Invitrogen, Waltham, MA, USA), both according to the supplier
doi: 10.1016/S1474-4422(14)70144-9 33
