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Astrocyte mitochondrial dysfunction can influence the homeostatic transport of Na + /K + -ATPase, thereby driving the accumulation of neurotransmitters such as glutamate and GABA (Genda et al., 2011

These sex-specific GHSTAT5 dynamics regulate different subsets of transcription factors and likely underlie differences in MASLD susceptibility, which is higher in males than in females [76]

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These responses disrupt the structural and functional integrity of the renal barrier and drive the progression of various renal injuries such as focal and segmental glomerulosclerosis (FSGS) and interstitial nephritis

Primarily animal and lab-based data