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10.1126/science.abp9563 Science 17 ChenY.WuJ.YanH.ChengY.WangY.YangY.et al (2020)

This process disrupts biological membranes, depletes antioxidants and ultimately increases oxidative stress (40)

2.10 Cell lines and cell culture This study used the human epidermoid carcinoma cell line KB-3-1 as the drug-sensitive cell line, and its MRP1-overexpressing cell line KB/CV60 (Supplementary Figure S1A), which was maintained in the medium with 1 g/mL of cepharanthine and 60 ng/mL of vincristine (Supplementary Figure S1B) by transfecting recombinant pcDNA3.1/MRP7 plasmids and the parental human ovarian adenocarcinoma cell line SKOV3 (Wang et al., 2021b) were also used

Catalase plays a significant role in hydrogen peroxide metabolism as a key regulator [28, 29, 152154]

By stimulating the innate immune system and encouraging the infiltration of inflammatory cells, interleukin-1 (IL-1) is an essential mediator of inflammation, host defense, and acute-phase responses