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Description

Lysine activates mTORC1 through the lysosomal SLC38A9 transporter, promoting ribosomal biosynthesis and protein translation while inhibiting autophagy-related genes

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Therefore, simultaneously targeting both pathways or combining these strategies with other therapies represents an effective approach to overcoming resistance driven by metabolic plasticity

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doi: 10.3389/fonc.2022.913736 200 GaoXHuangHPanCMeiZYinSZhouLet al

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Antioxidants (Basel, Zwitserland) , 12 (5), 1094

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