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Blocking a single pathway often triggers compensatory activation of alternative death mechanisms, limiting therapeutic efficacy

Brunger's and Dickey's groups designed a small protein snippet, or peptide, called SP9, that blocked synaptotagmin's calcium-triggered interaction with its cooperating proteins in mice

For general wellness purposes outside of athletic training contexts, this concern is less relevant

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Consistent with this, liver DCs with a high lipid content are immunogenic, inducing T-cell and NK-cell activation, while those with lower lipid concentrations are more tolerogenic and induce regulatory T cells 75