The glutathionylation of the Cys447 residue on the ZnF domain of FUS when exposed to oxidative stress in vitro eventually leads to a decrease in FUS solubility by promoting phase separation and aggregate formation 148
In this episode we discuss: Where microplastics accumulate in the body and why size matters How exposure happens: food, water, air, and household environments Links between microplastics and cardiovascular risk, inflammation, and dementia Effects on the gut microbiome and systemic health The Trojan horse effect: chemical additives like BPA, phthalates, and PFAS Ways to reduce exposure in daily life food storage, cookware, and household materials The role of diet, sleep, exercise, and detox pathways Targeted support: antioxidants, NAC, sulforaphane, fiber, and binders A functional medicine framework for resilience in a toxic environment Show notes: Microplastics: A real global threat for environment and food safety: A state of the art review by Ziani, K., et al
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Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness
J Exp Bot 44(1):127132
