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Notably, in vivo model is complex, in which increases in the abundance of colitogenic bacteria Akkermansia and Bacteroides in the gut of IL10 / mice have been reported in parallel with the administration of PTEN inhibitors

Abstract High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action

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