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Excess glucocorticoids (GCs) can induce neuronal damage in brain regions such as the hippocampus and SN through several mechanisms, including mitochondrial dysfunction, inhibition of inhibitory and excitatory synaptic transmission, and disruption of microglial or astrocytic functions, thereby exacerbating the progression of PD (3033)

Kappelmayer J, Nagy B Jr

Thus, the regulation of this enzymatic step is key to controlling NADPH levels within the cell

Researchers studying cellular repair pathways, angiogenesis, or connective tissue biology often find that examining both compounds within the same experimental framework yields richer comparative data