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Description

By lowering intracellular ROS and inhibiting NF-B-dependent transcriptional priming of NLRP3, Nrf2 activity functionally lowers inflammasome formation in sterile neuroinflammatory conditions such as PD

At the same time, patients lungs display lipid dysregulation associated with metabolic anomalies and ferroptosis, whereas rising ferritin light chain (FTL) levels correlate significantly with severe pulmonary pathological changes