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the WHO 2021 no-safe-level guideline

11: Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A, Sikiric S, Bekic D, Penovic T, Drazenovic D, Becejac T, Tepes M, Madzar Z, Novosel L, Beketic Oreskovic L, Oreskovic I, Stupnisek M, Boban Blagaic A, Dobric I

The FDA has noted both the lack of human clinical trial data and uncertainty about long-term safety

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The breadth of data was presented during a late-breaking symposium at the 2026 Scientific Sessions of the American Diabetes Association (ADA) in New Orleans, June 58, alongside the simultaneous publication of REIMAGINE 1 and 2 trial results in The Lancet Diabetes & Endocrinology and the REIMAGINE 3 trial results in The Lancet