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(6) IIRI + LM group: received 0.1 mL/10 g of Lactobacillus murinus (1 10 CFU/mL) daily via gavage for one week prior to IIRI surgery

31 Prior to the rise of IMF, BPOW was estimated to occur in 9% of buprenorphine initiations

Filardo G, et al

The FDA issued a safety alert in April 2025 noting 32 adverse event reports (20192024) including erectile dysfunction, depression, and suicidal ideation