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This muscle-sparing effect during weight loss is particularly valuable for maintaining metabolic rate, physical function, and long-term weight loss sustainability, as preservation of lean mass helps prevent the metabolic adaptations that typically promote weight regain

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These findings suggest that for people taking high-dose B12 supplements , consuming them on an empty stomach might be beneficial

42 Rationale for Investigating B 12 Deficiency in DCM On the Basis of Epidemiology Both B 12 deficiency and DCM are most prevalent in the elderly, and with estimates of 20% of B 12 deficiency, even a proportional prevalence among DCM patients would indicate a high rate of potential deficiency among the DCM population