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Canagliflozin has been shown to increase levels of beneficial high-density lipoprotein (HDL) cholesterol but also increases harmful low-density lipoprotein (LDL) cholesterol, thus producing no effect on total cholesterol ratios

Moreover, although Ang-1 and Ang-2 are not known drugs for protecting the glycocalyx, intervening in Ang-1 and Ang-2 may serve as targets for inhibiting glycocalyx degradation

Subsequent research must further clarify the role of the MGBA axis across varying malignancies, radiation site, and dose parameters (Li et al., 2022)

IFN- activity remains beyond the BBB resulting in "passive" neuroprotective effects on CNS inflammation