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A review of 12 available trials found a median sample size of just 48 participants and noted that eight of the twelve studies were funded by clinics selling the injections a significant source of bias

DOI: 10.1113/EP088637 [DOI] [PubMed] [Google Scholar] [61].Knekt P, Jarvinen R, Rissanen H, et al

Therefore, 5-oxoproline accumulates in body fluids and is excreted in the urine

Med Mycol 52:149155 Williams AJ, Buck BJ, Beyene MA (2012) Biological soil crusts in the Mojave Desert, USA: micromorphology and pedogenesis

In particular, monitoring of renal function should be undertaken, including urinalysis: albumin, creatinine, calcium/creatinine ratio, and blood creatinine to estimate the glomerular filtration rate (eGFR), due to the risk of developing nephrolithiasis and chronic kidney disease [128,131,132]