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The freeze-drying process already removed the water, so ice crystals cannot form

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For example, protein arginine methyltransferase 1 (PRMT1) has been reported to function as a suppressor of ferroptosis by increasing the level of asymmetrically dimethylated histone H4 on Arg 3 (H4R3me2a) to downregulate the expression of ACSL1 and then further decrease the lipid peroxidation[208]