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So taking methotrexate is rarely associated with increased infection risk unless youre also taking other medications at the same time, such as glucocorticoids, immunosuppressive disease-modifying antirheumatic drugs (DMARDs), or biologics

Folic acid supplementation is commonly recommended to reduce adverse effects without lessening efficacy

Pujol and Puel, 1999

actinomycetemcomitans leukotoxin reportedly affects different white blood cell populations and activates neutrophils to degranulate, resulting in lysosomal enzymatic reticular structure and matrix proteinase (Nylund et al., 2015)