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Because LaccID does not require H 2 O 2 and its activity is inherently selective for the cell surface (obviating the need for special probes such as BxxP), we wondered whether LaccID could be used for nontoxic mapping of cell-type-specific surfaceomes in complex biological settings

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These differences significantly impact the binding of inhibitors, leading to variations in their binding modes and affinities with the two enzymes

Dr Tripathi, study co-author Dr Brijesh Singh and their colleagues in Singapore, India, China and the US confirmed the association of homocysteine with NASH progression in preclinical models and humans

Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, et al