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L-carnitine and creatine are used as nutritional supplements and have been shown to positively affect muscle protein metabolism, typically at relatively high doses (L-carnitine 13 g/day

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The activated AKT will further activate the downstream regulatory pathway (the downstream target is mTOR), and the conversion process can be reversed by PTEN (a negative regulatory factor of PI3K) through dephosphorylation of PIP3 (229)

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We used the ratio of TMAO to TMA as the key outcome measure: normal reference ranges are 0.90

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