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Calorie intake and expenditure will determine weight loss or gain

These reports and our data indicate that, in addition to an extra copy of APP , the brains of individuals with DS are exposed to an unfavorable environment where A production is enhanced due to increased oxidative stress

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7.4 Inflammatory network regulation and precision therapy Although PGE2 is a classic inflammatory mediator, its downstream signaling pathways through different receptors (such as EP4) may be precisely regulated to achieve anti-inflammatory and tissue repair effects