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Cagrilintide and semaglutide work through different mechanisms and have different dosing schedules: Cagrilintide: Amylin receptor agonist Escalation: 0.6 mg 1.2 mg 2.4 mg weekly Three-step titration over 8 weeks Semaglutide: GLP-1 receptor agonist Escalation: 0.25 mg 0.5 mg 1.0 mg 1.7 mg 2.4 mg weekly Five-step titration over 16-20 weeks When combined in CagriSema, both peptides are dosed at 2.4 mg weekly, representing the maximum studied dose for each component

The compound's anti-inflammatory properties contribute to joint recovery by reducing synovial inflammation, a primary driver of pain and restricted movement

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Up to approximately 2 months after the last instillation, significant improvement in OSSI and OSPI scores, pain VAS, voided volumes, frequency, and nocturia also were reported

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