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studied the effect of ebselen treatment against the very high dose (20 Gy) -irradiation-induced toxicity in cultured cells and mice models (Table 2) [57]

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By contrast, the inhibition of sirtuin (Sirt)3 activates the NF-B signaling pathway, leading to worsening vascular inflammation, reduced NO production, increased ROS levels and decreased levels of L-arginine, further deteriorating vascular lesions (36)